Publications

2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999-1995 | 1994-1985

07 Science Journal Cover08 Curr Opin Journal Cover09 Cell Host Microbe Journal Cover04 Trends Microbiol Journal Cover05 J Biol Chem. Journal Cover06 Proc Natl Acad Sci USA Journal Cover

07 Science Journal Cover08 Curr Opin Journal Cover09 Cell Host Microbe Journal Cover10 Infect Imun Journal Cover11 MBio Journal Cover12 EMBO Rep Journal Cover

01 J Bacteriol Journal Cover02 Proc Natl Acad Sci USA 2 Journal Cover03 Infect Immun Journal Cover

2017

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI and Hultgren SJ
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
Nature. 2107 June 14. Doi: 10.1038/nature22972. [Epub ahead of print].
Sheikh A, Rashu R, Begum YA, Kuhlman FM, Ciorba MA, Hultgren SJ, Qadri F, and Fleckenstein JM
Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions
PLoS Negl Trop Dis. 2017 May 22;11(5).
Schreiber HL 4th, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, Hannan TJ, Roberts PL, Stapleton AE, Hooton TM, Livny J, Earl AM, and Hultgren SJ.
Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections
Sci Trans Med. 2017 Mar 22;9(382).
Kalas V, Pinkner JS, Hannan TJ, Hibbing ME, Dodson KW, Holehouse AS, Zhang H, Tolia NH, Gross ML, Pappu RV, Janetka J, and Hultgren SJ.
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
Sci Adv. 2017 Feb 10:3(2), e1601944.
Schreiber HL 4th, Spaulding CN, Dodson KW, Livny J, and Hultgren SJ.
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence.
Ann Transl Med. 2017 Jan; 5(2):28.

2016

O’Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, and Hultgren SJ.
A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease.
Nat Microbiol. 2016 Oct 31;2:16196.
Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL 4th, Pinkner JS, Bauman TM, Park AM,Desai A, Hultgren SJ, and Caparon MG.
Antibody-based therapy for Enterococcal catheter-associated urinary tract infections.
MBio. 2016 Oct 25;7(5).
Hufnagel DA, Evans ML, Greene SE, Pinkner JS, Hultgren SJ, and Chapman MR.
CRP-cAMP regulates csgD and biofilm formation by uropathogenic Escherichia coli.
J Bacteriol. 2016 Oct 3.
Mydock-McGrane L, Cusumano Z, Han Z, Binkely J, Kostakioti M, Hannan T, Pinkner JS, Klein RD, Kalas V, Crowley J, Rath NP, Hultgren SJ, and Janetka JW.
Anti-virulence C-mannosides as antibiotic-sparing, oral therapeutics for urinary tract infections.
J Med Chem. 2016 Sep 30.
Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, and Hultgren SJ.
Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe. 2016 Sept 20.
Floyd KA, Mitchell CA, Eberly AR, Colling SJ, Zhang EW, DePas W, Chapman MR, Conover M, Rogers BR, Hultgren SJ, and Hadjifrangiskou M.
The Ubil (VisC) Aerobic Ubiquinone Synthase is Required for Expression of Type 1 Pili, Biofilm Formation, and Pathogenesis in Uropathogenic Escherichia coli.
J Bacteriol. 2016 Sep 9;198(19):2662-72.
Shu Q, Krezel AM, Cusumano ZT, Pinkner J, Klein R, Hultgren SJ, and Frieden C.
Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
Proc Natl Acad Sci U S A. 2016 June 28;113(26):7130-5.
Conover MS, Hadjifrangiskou M, Palermo JJ, Hibbing ME, Dodson KW, and Hultgren SJ
Metabolic requirements of Escherichia coli in intracellular bacterial communities during urinary tract infection pathogenesis.
MBio. 2016 Apr 12;7(2).
Cusumano ZT, Klein RD, and Hultgren SJ.
Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections.
Microbiol Spectr. 2016 Apr;4(2).
Spaulding CN, and Hultgren SJ.
Adhesive Pili in TI Pathogenesis and Drug Development.
Pathogens. 2016 March 5(1):30.
Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, and Janetka JW
Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinty and Efficacy in the Treatment of Chronic UTI.
ChemMedChem. 2016 Feb. 11 (4):367-73.
O’Brien VP, Hannan TJ, Nielsen HV, and Hultgren SJ.
Drug and Vaccine Development for the treatment and prevention of urinary tract infections.
Microbiol Spectr. 2016 Feb;4(1).
Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL 4th, Park AM, Pinkner JS, Caparon MG, Hultgren SJ and Desai A.
Fibrinogen release and deposition on urinary catheters placed during urologic procedures.
J Urol. 2016 Jan 28 .

2015

Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, and Waksman G.
Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.
Cell. 2015 Dec 22.
Van Gerven N, Klein RD, Hultgren SJ, and Remaut H.
Bacterial amyloid formation: Structural insights into Curli Biogenesis.
Trends in Microbiol. 2015 Nov;23(11):693-706.
Spaulding CN, Dodson KW, Chapman MR, and Hultgren S.
Fueling the fire with fibers: Bacterial amyloids promote inflammatory.
Cell Host Microbe. 2015 Jul 8;18(1):1-2.
Werneburg GT, Henderson NS, Portnoy EB, Sarowar S, Hultgren SJ, Li H, and Thanassi DG.
The pilus usher controls protein interactions via domain masking and is functional as an oligomer
Nat Struct Mol Biol.. 2015 Jul;22(7);540-6. .
Greene SE, Hibbing ME, Janetka J, Chen SL, and Hultgren.
Human urine decreases function and expression of Type 1 Pili in uropathogenic Escherichia coli.
MBio. 2015 June 30;6(4)e00820.
Ozer A, Altuntas C, Izgi K, Bicer F, Hultgren S, Liu G, and Daneshgari F.
Advanced Glycation End Products Facilitate Bacterial Adherence in Urinary Tract Infection in Diabetic Mice.
Pathog Dis. 2015 Jul; 73(5).
Hibbing MD, Conover MS, and Hultgren SJ.
The unexplored relationship between urinary tract infections and the autonomic nervous system.
Auton Neurosci.. 2015 June 6.
Flores-Mireles AL, Walker JN, Caparon, and Hultgren SJ.
Urinary tract infections: epidemiology, mechanisms of infection and treatment options.
Nat Rev Microbiol. 2015 May:13(5):269-84.
Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, and Nizet V.
Role of Hypoxia Inducible Factor-1A (HIF-1a) in innate defense against uropathogenic Escherichia coli infection.
PLoS Pathog. 2015 Apr 30:11(4).
Ozer A, Altuntas CZ, Bicer F, Izgi K, Hultgren SJ, Liu G, and Daneshgari F.
Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice.
Pathog Dis. 2015 Apr; 73(3).
Goneau LW, Hannan TJ, MacPhee RA, Schwartz DJ, Macklaim JM, Gloor GB, Razvi H, Reid G, Hultgren SJ, and Burton JP.
Subinhibitory antibiotic therapy alters recrurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity.
mBio. 2015 Mar 31;6(2).
O’Brien VP, Hannan TJ, Schaeffer AJ and Hultgren SJ.
Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection.
Curr Opin Infect Dis. 2015 Feb;28(1):97-105. .
Klein RD, and Hultgren SJ.
Chaos controlled: discovery of a powerful amyloid inhibitor.
Mol Cell. 2015 Feb 5;57(3):391-3.
Nagamatsu K, Hannan TJ, Guest RL, Kostakioti M, Hadjifrangiskou M, Binkley J, Dodson K, Raivio TL, and Hultgren SJ.
Dysregulation of Escherichia coli a-hemolysin expression alters the course of acute and persistent urinary tract infection.
Proc Natl Acad Sci U S A. 2015 Feb 9.
Schwartz DJ, Conover MS, Hannan TJ, and Hultgren SJ.
Uropathogenic Escherichia coli Superinfection Enhances the Severity of Mouse Bladder Infection.
PLoS Pathog. 2015 Jan 8;11(1):e1004599.

2014

Engström P, Krishnan KS, Ngyuen BD, Chorell E, Normark J, Silver J, Bastidas RJ, Welch MD, Hultgren SJ, Wolf-Watz H, Valdivia RH, Almqvist, and Bergström S.
A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of Chlamydia trachomatis.
mBio. 2014 Dec 30;6(1).
Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, and Hultgren SJ.
Inhibition of cyclooxygenase-2 prevents chronic and recurrent cystitis.
EBioMedicine. 2014 Nov 3:1(1)46-57.
Greene, SE, Pinkner JS, Chorell E, Dodson KW, Shaffer CL, Conover MS, Livny J, Hadjifrangiskou M, Almqvist, and Hultgren S.
Pilicide ec240 Disrupts Virulence Circuuits in Uropathogenic E. coli.
mBIO. 2014 Oct 28;5(6):e02038.
The Dang H, Chorell E, Uvell H, Pinkner JS, Hultgren SJ, and Almqvist F.
Syntheses and biological evaluation of 2-amino-3-acyltetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.
Org Biomol Chem. 2014 Mar 28;12(12):1942-56..
Goyal P, Krasteva PV, Van Gerven N, Gubellini F, Van der Broeck I, Troupiotis-Tasailaki A, Jonckheere W, Pehau-Arnaudet G, Pinkner JS, Chapman MR, Hultgren SJ, Howorka S, Fronzes R, and Remaut H.
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG.
Nature. 2014 Sep 14. doi: 10.10nature13768. (Epub ahead of print) .
Flores-Mireles AL, Pinkner JS, Caparon MG, and Hultgren SJ.
EbpA vaccine antibodies block binding Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.
Sci Trans Med. 2014 Sep 17. 6:254ra127. DOI:10.1126/scitranslmed.3009384 .

2013

Korte-Berwanger M, Sakinc T, Kline K, Nielsen HV, Hultgren S, Gatermann SG.
Significance of the D-serine-deaminase and D-serine metabolism of Staphylococcus saprophyticus for virulence.
Infect Immun. 2013 Nov.
Silverman JA, Schreiber HL 4th, Hooton TM, Hultgren SJ..
From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections.
Curr Urol Rep. 2013 Oct;14(5):448-56.
Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.
Pilin and Sortase Residues Critical for Endocarditis- and Biofilm-Associated Pilus Biogenesis in Enterococcus faecalis.
J Bacteriol. 2013 Oct;195(19):4484-95.
Guckes KR, Kostakioti M, Breland EJ, Gu AP, Shaffer CL, Martinez CR 3rd, Hultgren SJ, Hadjifrangiskou M.
Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor.
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16592-7.
Totsika M, Kostakioti M, Hannan TJ, Upton M, Beatson SA, Janetka JW, Hultgren SJ, Schembri MA
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic escherichia coli ST131.
J Infect Dis. 2013 Sep;208(6):921-8.
Schwartz DJ, Kalas V, Pinkner JS, Chen SL, Spaulding CN, Dodson KW, Hultgren SJ.
Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15530-7.
Hung C, Zhou Y, Pinkner JS, Dodson KW, Crowley JR, Heuser J, Chapman MR, Hadjifrangiskou M, Henderson JP, Hultgren SJ.
Escherichia coli biofilms have an organized and complex extracellular matrix structure.
MBio. 2013 Sep 10;4(5):e00645-13.
Hannan TJ, Hooton TM, Hultgren SJ.
Estrogen and recurrent UTI: what are the facts?
Sci Transl Med. 2013 Jun 19;5(190):190.
Watson ME Jr, Nielsen HV, Hultgren SJ, Caparon MG.
Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes.
Infect Immun. 2013 May;81(5):1606-17..
Frank KL, Guiton PS, Barnes AM, Manias DA, Chuang-Smith ON, Kohler PL, Spaulding AR, Hultgren SJ, Schlievert PM, Dunny GM.
AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis.
Infect Immun. 2013 May;81(5):1696-708.
Chen SL, Wu M, Henderson JP, Hooton TM, Hibbing ME, Hultgren SJ, Gordon JI.
Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection.
Sci Transl Med. 2013 May 8;5(184):184.
Geibel S, Procko E, Hultgren SJ, Baker D, Waksman G.
Structural and energetic basis of folded-protein transport by the FimD usher.
Nature. 2013 Apr 11;496(7444):243-6.
Kostakioti M, Hadjifrangiskou M, Hultgren SJ.
Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.
Cold Spring Harb Perspect Med. 2013 Apr 1;3(4).
Allen WJ, Phan G, Hultgren SJ, Waksman G.
Dissection of pilus tip assembly by the FimD usher monomer.
J Mol Biol. 2013 Mar 11;425(5):958-67.
Monack DM, Hultgren SJ.
The complex interactions of bacterial pathogens and host defenses.
Curr Opin Microbiol. 2013 Feb;16(1):1-3.
Guiton PS, Hannan TJ, Ford B, Caparon MG, Hultgren SJ
Enterococcus faecalis Overcomes Foreign Body-Mediated Inflammation To Establish Urinary Tract Infections.
Infect Immun. 2013 Jan;81(1):329-39.

2012

Kline KA, Schwartz DJ, Gilbert NM, Hultgren SJ, Lewis AL.
Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli.
Infect Immun. 2012 Dec;80(12):4186-94.
Ford B, Verger D, Dodson K, Volkan E, Kostakioti M, Elam J, Pinkner J, Waksman G, Hultgren SJ
Structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket.
J Bacteriol. 2012 Dec;194(23):6390-7.
Hadjifrangiskou M, Gu AP, Pinkner JS, Kostakioti M, Zhang EW, Greene SE, Hultgren SJ.
Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors
J Bacteriol. 2012 Nov;194(22):6195-205.
Floyd RV, Upton M, Hultgren SJ, Wray S, Burdyga TV, Winstanley C.
Escherichia coli-mediated impairment of ureteric contractility is UPEC-specific.
J Infect Dis. 2012 Nov 15;206(10):1589-96.
Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. .
Combination small molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.
Antimicrob Agents Chemother. 2012 Sep;56(9):4738-45.
Kostakioti M, Hadjifrangiskou M, Cusumano CK, Hannan TJ, Janetka JW, Hultgren SJ.
Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.
Infect Immun. 2012 Aug;80(8):2826-34.
Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.
The Metal Ion-Dependent Adhesion Site Motif of the Enterococcus faecalis EbpA Pilin Mediates Pilus Function in Catheter-Associated Urinary Tract Infection.
MBio. 2012 Jul 24;3(4).
Volkan E, Ford BA, Pinkner JS, Dodson KW, Henderson NS, Thanassi DG, Waksman G, Hultgren SJ .
Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine.
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9563-8.
Hannan TJ, Totsika M, Mansfield KJ, Moore KH, Schembri MA, Hultgren SJ.
Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection.
FEMS Microbiol Rev. 2012 May;36(3):616-48.
Chorell E, Pinkner JS, Bengtsson C, Banchelin TS, Edvinsson S, Linusson A, Hultgren SJ, Almqvist F.
Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study.
Bioorg Med Chem. 2012 May 1;20(9):3128-42.
Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW.
Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides.
J Med Chem. 2012 Apr 26;55(8):3945-59.
Shu Q, Crick SL, Pinkner JS, Ford B, Hultgren SJ, Frieden C..
The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6502-7.
Chorell E, Pinkner JS, Bengtsson C, Edvinsson S, Cusumano CK, Rosenbaum E, Johansson LB, Hultgren SJ, Almqvist F.
Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms.
Chemistry. 2012 Apr 10;18(15):4522-32.
Klinth JE, Pinkner JS, Hultgren SJ, Almqvist F, Uhlin BE, Axner O.
Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections?
Eur Biophys J. 2012 Mar;41(3):285-95.
Lin LY, Tiemann KM, Li Y, Pinkner JS, Walker JN, Hultgren SJ, Hunstad DA, Wooley KL.
Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.
J Am Chem Soc. 2012 Mar 7;134(9):3938-41.
Horvath I, Weise CF, Andersson EK, Chorell E, Sellstedt M, Bengtsson C, Olofsson A, Hultgren SJ, Chapman M, Wolf-Watz M, Almqvist F, Wittung-Stafshede P.
Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.
J Am Chem Soc. 2012 Feb 22;134(7):3439-44.

2011

Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ.
Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors.
Science Transl Med. 2011 Nov 16;3(109).
Schwartz DJ, Chen SL, Hultgren SJ, Seed PC.
Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection.
Infect Immun. 2011 Oct;79(10):4250-9.
Kline KA, Schwartz DJ, Lewis WG, Hultgren SJ, Lewis AL.
Immune Activation and Suppression by Group B Streptococcus in a Murine Model of Urinary Tract Infection.
Infect Immun. 2011 Sep;79(9):3588-95.
Nenninger AA, Robinson LS, Hammer ND, Epstein EA, Badtke MP, Hultgren SJ, Chapman MR.
CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation.
Mol Microbiol. 2011 Jul;81(2):486-99.
Phan G, Remaut H, Wang T, Allen WJ, Pirker KF, Lebedev A, Henderson NS, Geibel S, Volkan E, Yan J, Kunze MB, Pinkner JS, Ford B, Kay CW, Li H, Hultgren SJ, Thanassi DG, Waksman G.
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.
Nature. 2011 Jun 2;474(7349):49-53.
Hadjifrangiskou M, Kostakioti M, Chen SL, Henderson JP, Greene SE, Hultgren SJ.
A central metabolic circuit controlled by QseC in pathogenic Escherichia coli.
Mol Microbiol. 2011 Jun;80(6):1516-29.
Hadjifrangiskou M, Kostakioti M, Hultgren SJ.
Antitoxins: therapy for stressed bacteria.
Nat Chem Biol. 2011 Jun;7(6):345-7.
Tenke P, Köves B, Nagy K, Hultgren SJ, Mendling W, Wullt B, Grabe M, Wagenlehner FM, Cek M, Pickard R, Botto H, Naber KG, Bjerklund Johansen TE.
Update on biofilm infections in the urinary tract.
World J Urol. 2011 May 18.
Horvath DJ Jr, Li B, Casper T, Partida-Sanchez S, Hunstad DA, Hultgren SJ, Justice SS.
Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli.
Microbes Infect. 2011 May;13(5):426-37.
Chorell E, Bengtsson C, Sainte-Luce Banchelin T, Das P, Uvell H, Sinha AK, Pinkner JS, Hultgren SJ, Almqvist F.
Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity.
Eur J Med Chem. 2011 Apr;46(4):1103-16.
Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T.
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.
Structure. 2011 Feb 9;19(2):192-202.

2010

Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F.
Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.
J Med Chem. 2010 Aug 12;53(15):5690-5.
Hannan TJ, Mysorekar IU, Hung CS, Isaacson-Schmid ML, Hultgren SJ.
Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection.
PLoS Pathog. 2010 Aug 12;6(8).
Guiton PS, Hung CS, Hancock LE, Caparon MG, Hultgren SJ.
Enterococcal Biofilm Formation and Virulence in an Optimized Murine Model of Foreign Body-Associated Urinary Tract Infections.
Infect Immun. 2010 Aug 9.
Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW.
Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J Med Chem. 2010 Jun 24;53(12):4779-92.
Kline KA, Dodson KW, Caparon MG, Hultgren SJ.
A tale of two pili: assembly and function of pili in bacteria.
Trends Microbiol. 2010 May;18(5):224-32.
Anderson GG, Goller CC, Justice S, Hultgren SJ, Seed PC.
Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis.
Infect Immun. 2010 Mar;78(3):963-75.
Li Q, Ng TW, Dodson KW, Shu Kin So S, Bayle KM, Pinkner JS, Scarlata S, Hultgren SJ, Thanassi DG.
The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili.
Mol Microbiol. 2010 Feb 24.
Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ.
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.
Infect Immun. 2010 Feb 22.
Cusumano CK, Hung CS, Chen SL, Hultgren SJ.
Virulence Plasmid Harbored by Uropathogenic E. coli Functions in Acute Stages of Pathogenesis.
Infect Immun. 2010 Feb 1.
Ford B, Rêgo AT, Ragan TJ, Pinkner J, Dodson K, Driscoll PC, Waksman G, Hultgren S.
Structural homology between the C-terminal domain of the PapC usher and its plug.
J Bacteriol. 2010 Jan 29.

2009

Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ.
Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding.
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22439-44.
Pinkner JS, Cegelski L, Hammer ND, Cusumano CK, Hung CS, Chorell E, Aberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ.
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.
Nat Chem Biol. 2009 Dec;5(12):913-9.
Waksman G, Hultgren SJ.
Structural biology of the chaperone-usher pathway of pilus biogenesis.
Nature Rev Microbiol. 2009 Nov;7(11):765-74.
Cusumano CK, Hultgren SJ.
Bacterial adhesion – A source of alternate antibiotic targets.
IDrugs. 2009 Nov;12(11):699-705.
Guiton PS, Hung CS, Kline KA, Roth R, Kau AL, Hayes E, Heuser J, Dodson KW, Caparon MG, Hultgren SJ.
Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development.
Infect Immun. 2009 Sep;77(9):3626-38.
Hung CS, Dodson KW, Hultgren SJ.
A murine model of urinary tract infection.
Nature Protoc. 2009;4(8):1230-43.
Kostakioti M, Hadjifrangiskou M, Pinkner JS, Hultgren SJ.
QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
Mol Microbiol. 2009 Sep;73(6):1020-31.
Czaja CA, Stamm WE, Stapleton AE, Roberts PL, Hawn TR, Scholes D, Samadpour M, Hultgren SJ, Hooton TM.
Prospective cohort study of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection in women.
J Infect Dis. 2009 Aug 15;200(4):528-36.
Mysorekar IU, Isaacson-Schmid M, Walker JN, Mills JC, Hultgren SJ.
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection.
Cell Host Microbe. 2009 May 8;5(5):463-75.
Kline KA, Kau AL, Chen SL, Lim A, Pinkner JS, Rosch J, Nallapareddy SR, Murray BE, Henriques-Normark B, Beatty W, Caparon MG, Hultgren SJ.
Mechanism for sortase localization and role in efficient pilus assembly in Enterococcus faecalis.
J Bacteriol. 2009 Mar 13.
Hultgren S, Goldstein JM, Delancey JO, Bandstra ES, Brady KT, Brown JS, Deng HW, Dunaif A, Ehrmann DA, Mayer EA, Sinha R, Tobet S, Levine JE.
The vital role of ORWH.
Science. 2009 Feb 20;323(5917):1009-10.
Henderson JP, Crowley JR, Pinkner JS, Walker JN, Tsukayama P, Stamm WE, Hooton TM, Hultgren SJ.
Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli.
PLoS Pathog. 2009 Feb;5(2):e1000305.
Nenninger AA, Robinson LS, Hultgren SJ.
Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF.
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):900-5. Epub 2009 Jan 8.

2008

Ingersoll MA, Kline KA, Nielsen HV, Hultgren SJ.
G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.
Cell Microbiol. 2008 Dec;10(12):2568-78.
Verger D, Rose RJ, Paci E, Costakes G, Daviter T, Hultgren S, Remaut H, Ashcroft AE, Radford SE, Waksman G.
Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF.
Structure. 2008 Nov 12;16(11):1724-31.
Rosen DA, Hung CS, Kline KA, Hultgren SJ.
Streptozocin-induced diabetic mouse model of urinary tract infection.
Infect Immun. 2008 Sep;76(9):4290-8.
Remaut H, Tang C, Henderson NS, Pinkner JS, Wang T, Hultgren SJ, Thanassi DG, Waksman G, Li H.
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.
Cell. 2008 May 16;133(4):640-52.
Rosen DA, Pinkner JS, Walker JN, Elam JS, Jones JM, Hultgren SJ.
Molecular Variations in Klebsiella pneumoniae and Escherichia coli FimH Affect Function and Pathogenesis in the Urinary Tract.
Infect Immun. 2008 May 12.
Berg V, Das P, Chorell E, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F.
Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.
Bioorg Med Chem Lett. 2008 May 7.
Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slättegård R, Wyns L, Oscarson S, De Greve H, Hultgren S, Bouckaert J.
Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.
PLoS ONE. 2008 Apr 30;3(4):e2040.
Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ.
Utilization of an IBC Pathway in Klebsiella pneumoniae Urinary Tract Infection and the Effects of FimK on Type 1 Pilus Expression.
Infect Immun. 2008 Apr 14.
Hultgren S, Elam J.
Infectious disease and women’s health.
Nat Rev Microbiol. 2008 Apr;6(4):254.
Justice SS, Hunstad DA, Cegelski L, Hultgren SJ.
Morphological plasticity as a bacterial survival strategy.
Nat Rev Microbiol. Feb 2008.
Hannan TJ, Mysorekar IU, Chen SL, Walker JN, Jones JM, Pinkner JS, Hultgren SJ, Seed PC.
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis.
Mol Microbiol. 2008 Jan 7;67(1):116-128.
Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ.
The biology and future prospects of antivirulence therapies.
Nat Rev Microbiol. 2008 Jan;6(1):17-27.

2007

Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ.
Detection of intracellular bacterial communities in human urinary tract infection.
PLoS Med. 2007 Dec 18;4(12):e329.
Wright KJ, Seed PC, Hultgren SJ.
Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.
Cell Microbiol. 2007 Sep;9(9):2230-41.
Lee YM, Dodson KW, Hultgren SJ.
Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli.
J Bacteriol. 2007 Jul;189(14):5276-83.
Verger D, Bullitt E, Hultgren SJ, Waksman G.
Crystal structure of the P pilus rod subunit PapA.
PLoS Pathog. 2007 May 18;3(5):e73.
Aberg V, Fällman E, Axner O, Uhlin BE, Hultgren SJ, Almqvist F.
Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.
Mol Biosyst. 2007 Mar;3(3):214-8.
Garofalo CK, Hooton TM, Martin SM, Stamm WE, Palermo JJ, Gordon JI, Hultgren SJ.
Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation.
Infect Immun. 2007 Jan;75(1):52-60.

2006

Justice SS, Hunstad DA, Seed PC, Hultgren SJ.
Filamentation by Escherichia coli subverts innate defenses during urinary tract infection.
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19884-9.
Verger D, Miller E, Remaut H, Waksman G, Hultgren S.
Molecular mechanism of P pilus termination in uropathogenic Escherichia coli.
EMBO Rep. 2006 Dec;7(12):1228-32.
Pinkner JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N, Hedenström M, Larsson A, Seed P, Waksman G, Hultgren SJ, Almqvist F.
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17897-902.
Miller E, Garcia T, Hultgren S, Oberhauser AF.
The mechanical properties of E. coli type 1 pili measured by atomic force microscopy techniques.
Biophys J. 2006 Nov 15;91(10):3848-56.
Mysorekar IU, Hultgren SJ.
Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract.
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14170-5.
Aberg V, Sellstedt M, Hedenstrom M, Pinkner JS, Hultgren SJ, Almqvist F.
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-Targeting virulence of uropathogenic E. coli.
Bioorg Med Chem. 2006 Aug 10.
Justice SS, Lauer SR, Hultgren SJ, Hunstad DA.
Maturation of intracellular Escherichia coli communities requires SurA.
Infect Immun. 2006 Aug;74(8):4793-800.
Remaut H, Rose RJ, Hannan TJ, Hultgren SJ, Radford SE, Ashcroft AE, Waksman G.
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism.
Mol Cell. 2006 Jun 23;22(6):831-42.
K.J. Wright and S.J. Hultgren.
Sticky Fibers and Uropathogenesis: Bacterial Adhesins in the Urinary Tract.
Future Microbiol. 2006 Jun;1:75-87. Review.
James G. Bann, Lynette Cegelski, and Scott J. Hultgren.
LRP6 Holds the Key for the Entry of Anthrax Toxin.
Cell. (2006) 124, 3-5.
Robinson LS, Ashman EM, Hultgren SJ, Chapman MR.
Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein.
Mol. Microbiol. 2006 Feb;59(3):870-881.

2005

Wright, K.J., Seed, P.C., and S.J. Hultgren.
Uropathogenic Escherichia coli Flagella Aid in Efficient Urinary Tract Colonization
Infection and Immunity. 2005, in press.
Justice SS, Hunstad DA, Harper JR, Duguay AR, Pinkner JS, Bann J, Frieden C, Silhavy TJ, Hultgren SJ.
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli.
J Bacteriol. 2005 Nov;187(22):7680-6.
Wright et al.,
Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization.
Infection and Immunity. 2005; 73(11):7657-7668.
Hunstad DA, Justice SS, Hung CS, Lauer SR, Hultgren SJ.
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli.
Infect Immun. 2005 Jul;73(7):3999-4006.
Seed PC, Hultgren SJ.
Blueprinting the regulatory response of Escherichia coli to the urinary tract.
Trends Microbiol. 2005 Jun;13(6):246-8.
Kau AL, Martin SM, Lyon W, Hayes E, Caparon MG, Hultgren SJ.
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice.
Infect Immun. 2005 Apr;73(4):2461-8.
Ohlsson J, Larsson A, Haataja S, Alajaaski J, Stenlund P, Pinkner JS, Hultgren SJ, Finne J, Kihlberg J, Nilsson UJ.
Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins.
Org Biomol Chem. 2005 Mar 7;3(5):886-900. Epub 2005 Feb 04.
Larsson A, Johansson SM, Pinkner JS, Hultgren SJ, Almqvist F, Kihlberg J, Linusson A.
Multivariate Design, Synthesis, and Biological Evaluation of Peptide Inhibitors of FimC/FimH Protein-Protein Interactions in Uropathogenic Escherichia coli.
J Med Chem. 2005 Feb 24;48(4):935-945.
Schwan WR, Beck MT, Hultgren SJ, Pinkner J, Woolever NL, Larson T.
Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors.
Infect Immun. 2005 Feb;73(2):1226-31.
Kau AL, Hunstad DA, Hultgren SJ.
Interaction of uropathogenic Escherichia coli with host uroepithelium.
Curr Opin Microbiol. 2005 Feb;8(1):54-9.
Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, Wuhrer M, Hung CS, Pinkner J, Slattegard R, Zavialov A, Choudhury D, Langermann S, Hultgren SJ, Wyns L, Klemm P, Oscarson S, Knight SD, De Greve H.
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.
Mol Microbiol. 2005 Jan;55(2):441-55.

2004

Bann JG, Pinkner JS, Frieden C, Hultgren SJ.
Catalysis of protein folding by chaperones in pathogenic bacteria.
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17389-93. Epub 2004 Dec 06..
Sauer FG, Remaut H, Hultgren SJ, Waksman G.
Fiber assembly by the chaperone-usher pathway.
Biochim Biophys Acta. 2004 Nov 11;1694(1-3):259-67. Review.
Anderson GG, Martin SM, Hultgren SJ.
Host subversion by formation of intracellular bacterial communities in the urinary tract.
Microbes Infect. 2004 Oct;6(12):1094-101. Review.
Anderson GG, Dodson KW, Hooton TM, Hultgren SJ.
Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis.
Trends Microbiol. 2004 Sep;12(9):424-30.
Bann JG, Hultgren SJ.
Structural biology: anthrax hijacks host receptor.
Nature. 2004 Aug 19;430(7002):843-4. No abstract available.
Lee YM, DiGiuseppe PA, Silhavy TJ, Hultgren SJ.
P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli.
J Bacteriol. 2004 Jul;186(13):4326-37.
Roberts JA, Kaack MB, Baskin G, Chapman MR, Hunstad DA, Pinkner JS, Hultgren SJ.
Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein.
J Urol. 2004 Apr;171(4):1682-5.
Bates JM, Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren SJ, Kumar S.
Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.
Kidney Int. 2004 Mar;65(3):791-7.
Sexton JA, Pinkner JS, Roth R, Heuser JE, Hultgren SJ, Vogel JP.
The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth.
J Bacteriol. 2004 Mar;186(6):1658-66.
Justice SS, Hung C, Theriot JA, Fletcher DA, Anderson GG, Footer MJ, Hultgren SJ.
Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis.
Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5): 1333-8. Epub 2004 Jan 22.

2003

Lee YM, Almqvist F, Hultgren SJ.
Targeting virulence for antimicrobial chemotherapy.
Curr Opin Pharmacol. 2003 Oct;3(5):513-9.
Anderson GG, Palermo JJ, Schilling JD, Roth R, Heuser J, Hultgren SJ.
Intracellular bacterial biofilm-like pods in urinary tract infections.
Science. 2003 Jul 4;301(5629):105-7.
Chapman MR, Robinson LS, Hultgren SJ.
Escherichia coli’s How-To Guide for Forming Amyloid.
ASM News. 2003. 69:3 pp. 121-126.
Larsson A, Ohlsson J, Dodson KW, Hultgren SJ, Nilsson U, Kihlberg J.
Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides.
Bioorg Med Chem. 2003 May 15;11(10):2255-2261.
Barnhart MM, Sauer FG, Pinkner JS, Hultgren SJ.
Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly.
J Bacteriol. 2003 May;185(9):2723-30.
Emtenas H, Carlsson M, Pinkner JS, Hultgren SJ, Almqvist F.
Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria.
Org Biomol Chem. 2003 Apr 21;1(8):1308-14.
Schilling JD, Martin SM, Hung CS, Lorenz RG, Hultgren SJ.
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli.
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4203-8. Epub 2003 Mar 24.
Schilling JD, Martin SM, Hunstad DA, Patel KP, Mulvey MA, Justice SS, Lorenz RG, Hultgren SJ.
CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli.
Infect Immun. 2003 Mar;71(3):1470-80.

2002

Emtenas H, Ahlin K, Pinkner JS, Hultgren SJ, Almqvist F.
Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria.
J Comb Chem. 2002 Nov-Dec;4(6):630-9.
Sauer FG, Pinkner JS, Waksman G, Hultgren SJ.
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation.
Cell. 2002 Nov 15;111(4):543-51.
Thanassi DG, Stathopoulos C, Dodson K, Geiger D, Hultgren SJ.
Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis.
J Bacteriol. 2002 Nov;184(22):6260-9.
Jones CH, Dexter P, Evans AK, Liu C, Hultgren SJ, Hruby DE.
Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin.
J Bacteriol. 2002 Oct;184(20):5762-71.
Schilling JD, Hultgren SJ, Lorenz RG.
Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract.
Int Rev Immunol. 2002 Jul-Oct;21(4-5):291-304.
Darby C, Hultgren SJ.
Innate defense evicts bacterial squatters.
Nat Immunol. 2002 Jul;3(7):602-4.
Knight SD, Choudhury D, Hultgren S, Pinkner J, Stojanoff V, Thompson A.
Structure of the S pilus periplasmic chaperone SfaE at 2.2 A resolution.
Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1016-22.
Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, DeFusco A, Auguste CG, Strouse R, Langermann S, Waksman G, Hultgren SJ.
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection.
Mol Microbiol. 2002 May;44(4):903-15.
Mysorekar IU, Mulvey MA, Hultgren SJ, Gordon JI.
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli.
J Biol Chem. 2002 Mar 1;277(9):7412-9. Epub 2001 Dec 13.
Chapman MR, Robinson LS, Pinkner JS, Roth R, Heuser J, Hammar M, Normark S, Hultgren SJ.
Role of Escherichia coli curli operons in directing amyloid fiber formation.
Science. 2002 Feb 1;295(5556):851-5.
Bann JG, Pinkner J, Hultgren SJ, Frieden C.
Real-time and equilibrium (19)F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD.
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):709-14. Epub 2002 Jan 15.

2001

Svensson A, Larsson A, Emtenas H, Hedenstrom M, Fex T, Hultgren SJ, Pinkner JS, Almqvist F, Kihlberg J.
Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli.
Chembiochem. 2001 Dec 3;2(12):915-8.
Smith CL, Hultgren SJ.
Bacteria thread the needle.
Nature. 2001 Nov 1;414(6859):29-31.
Mulvey MA, Schilling JD, Hultgren SJ.
Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection.
Infect Immun. 2001 Jul;69(7):4572-9.
Schilling JD, Mulvey MA, Hultgren SJ.
Dynamic interactions between host and pathogen during acute urinary tract infections.
Urology. 2001 Jun;57(6 Suppl 1):56-61.
Hultgren SJ.
Uropathogenic escherichia coli: interactions with bladder epithelium.
Urology. 2001 Jun;57(6 Suppl 1):105-6.
Hung DL, Raivio TL, Jones CH, Silhavy TJ, Hultgren SJ.
Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili.
EMBO J. 2001 Apr 2;20(7):1508-1.
Schilling JD, Mulvey MA, Hultgren SJ.
Structure and function of Escherichia coli type 1 pili: new insight into the pathogenesis of urinary tract infections.
J Infect Dis. 2001 Mar 1;183 Suppl 1:S36-40.
Schilling JD, Mulvey MA, Vincent CD, Lorenz RG, Hultgren SJ.
Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism.
J Immunol. 2001 Jan 15;166(2):1148-55.
Dodson KW, Pinkner JS, Rose T, Magnusson G, Hultgren SJ, Waksman G.
Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell. 2001 Jun 15;105(6):733-43.

2000

Sauer FG, Barnhart M, Choudhury D, Knight SD, Waksman G, Hultgren SJ.
Chaperone-assisted pilus assembly and bacterial attachment.
Curr Opin Struct Biol. 2000 Oct;10(5):548-56.
Mahmood A, Engle MJ, Hultgren SJ, Goetz GS, Dodson K, Alpers DH.
Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli.
Biochim Biophys Acta. 2000 Sep 1;1523(1):49-55.
Mulvey MA, Hultgren SJ.
Cell biology. Bacterial spelunkers.
Science. 2000 Aug 4;289(5480):732-3.
Thanassi DG, Hultgren SJ.
Multiple pathways allow protein secretion across the bacterial outer membrane.
Curr Opin Cell Biol. 2000 Aug;12(4):420-30.
Saulino ET, Bullitt E, Hultgren SJ.
Snapshots of usher-mediated protein secretion and ordered pilus assembly.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9240-5.
Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ.
Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8829-35.
Emtenas H, Soto G, Hultgren SJ, Marshall GR, Almqvist F.
Stereoselective synthesis of optically active beta-lactams, potential inhibitors of pilus assembly in pathogenic bacteria.
Org Lett. 2000 Jul 13;2(14):2065-7.
Barnhart MM, Pinkner JS, Soto GE, Sauer FG, Langermann S, Waksman G, Frieden C, Hultgren SJ.
PapD-like chaperones provide the missing information for folding of pilin proteins.
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7709-14.
Stathopoulos C, Hendrixson DR, Thanassi DG, Hultgren SJ, St Geme JW 3rd, Curtiss R 3rd.
Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.
Microbes Infect. 2000 Jul;2(9):1061-72.
Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ.
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.
EMBO J. 2000 Jun 15;19(12):2803-12.
Lopez-Boado YS, Wilson CL, Hooper LV, Gordon JI, Hultgren SJ, Parks WC.
Bacterial exposure induces and activates matrilysin in mucosal epithelial cells.
J Cell Biol. 2000 Mar 20;148(6):1305-15.
Krasan GP, Sauer FG, Cutter D, Farley MM, Gilsdorf JR, Hultgren SJ, St Geme JW 3rd
Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili.
Mol Microbiol. 2000 Mar;35(6):1335-47.
Langermann S, Mollby R, Burlein JE, Palaszynski SR, Auguste CG, DeFusco A, Strouse R, Schenerman MA, Hultgren SJ, Pinkner JS, Winberg J, Guldevall L, Soderhall M, Ishikawa K, Normark S, Koenig S.
Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.
J Infect Dis. 2000 Feb;181(2):774-8.
Sauer FG, Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ.
Bacterial pili: molecular mechanisms of pathogenesis.
Curr Opin Microbiol. 2000 Feb;3(1):65-72.
Sauer FG, Knight SD, Waksman and GJ, Hultgren SJ.
PapD-like chaperones and pilus biogenesis.
Semin Cell Dev Biol. 2000 Feb;11(1):27-34.

1999-1995

Goetz GS, Mahmood A, Hultgren SJ, Engle MJ, Dodson K, Alpers DH.
Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes.
Infect Immun. 1999 Nov;67(11):6161-3. PMID: 10531281.
Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC.
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.
Science. 1999 Oct 1;286(5437):113-7. PMID: 10506557.
Sauer FG, Futterer K, Pinkner JS, Dodson KW, Hultgren SJ, Waksman G.
Structural basis of chaperone function and pilus biogenesis.
Science. 1999 Aug 13;285(5430):1058-61. PMID: 10446050.
Choudhury D, Thompson A, Stojanoff V, Langermann S, Pinkner J, Hultgren SJ, Knight SD.
X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli.
Science. 1999 Aug 13;285(5430):1061-6. PMID: 10446051.
Hung DL, Pinkner JS, Knight SD, Hultgren SJ.
Structural basis of chaperone self-capping in P pilus biogenesis.
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8178-83. PMID: 10393968.
Soto GE, Hultgren SJ.
Bacterial adhesins: common themes and variations in architecture and assembly.
J Bacteriol. 1999 Feb;181(4):1059-71. Review. No abstract available. PMID: 9973330.
Hung DL, Knight SD, Hultgren SJ.
Probing conserved surfaces on PapD.
Mol Microbiol. 1999 Feb; 31(3):773-83. PMID: 10048022.
Hung DL, Hultgren SJ.
Pilus biogenesis via the chaperone/usher pathway: an integration of structure and function.
J Struct Biol. 1998 Dec 15;124(2-3):201-20. Review. PMID: 10049807.
Mulvey MA, Lopez-Boado YS, Wilson CL, Roth R, Parks WC, Heuser J, Hultgren SJ.
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli.
Science. 1998 Nov 20;282(5393):1494-7. Erratum in: Science 1999 Feb 5;283(5403):795. PMID: 9822381.
Karlsson KF, Walse B, Drakenberg T, Roy S, Bergquist KE, Pinkner JS, Hultgren SJ, Kihlberg J.
Binding of peptides in solution by the Escherichia coli chaperone PapD as revealed using an inhibition ELISA and NMR spectroscopy.
Bioorg Med Chem. 1998 Nov;6(11):2085-101. PMID: 9881099.
Soto GE, Dodson KW, Ogg D, Liu C, Heuser J, Knight S, Kihlberg J, Jones CH, Hultgren SJ.
Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus.
EMBO J. 1998 Nov 2;17(21):6155-67. PMID: 9799225.
Saulino ET, Thanassi DG, Pinkner JS, Hultgren SJ.
Ramifications of kinetic partitioning on usher-mediated pilus biogenesis.
EMBO J. 1998 Apr 15;17(8):2177-85. PMID: 9545231.
Thanassi DG, Saulino ET, Hultgren SJ.
The chaperone/usher pathway: a major terminal branch of the general secretory pathway.
Curr Opin Microbiol. 1998 Apr;1(2):223-31. Review. PMID: 10066482.
Thanassi DG, Saulino ET, Lombardo MJ, Roth R, Heuser J, Hultgren SJ.
The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane.
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3146-51. PMID: 9501230.
Almqvist F, Guillaume D, Marshall GR, and Hultgren SJ.
Efficient Regioselective Synthesis of Enantiomerically Pure 4-Hydroxymethyl-D2 Thiazoline.
Tetrahedron Lett. 1998; 39: 2293-2294.
Jones CH, Danese PN, Pinkner JS, Silhavy TJ, Hultgren SJ.
The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems.
EMBO J. 1997 Nov 3;16(21):6394-406. PMID: 9351822.
Walse B, Kihlberg J, Karlsson KF, Nilsson M, Wahlund KG, Pinkner JS, Hultgren SJ, Drakenberg T.
Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus subunit bound by the Escherichia coli PapD chaperone.
FEBS Lett. 1997 Jul 21;412(1):115-20. PMID: 9257702.
Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner JS, Burlein J, Barren P, Koenig S, Leath S, Jones CH, Hultgren SJ.
Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination.
Science. 1997 Apr 25;276(5312):607-11. PMID: 9110982.
Bullitt E, Jones CH, Striker R, Soto G, Jacob-Dubuisson F, Pinkner J, Wick MJ, Makowski L, Hultgren SJ.
Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper.
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12890-5. PMID: 8917515.
Nilsson U, Striker RT, Hultgren SJ, Magnusson G.
PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein.
Bioorg Med Chem. 1996 Nov;4(11):1809-17. PMID: 9007266.
St Geme JW, Pinkner JS 3rd, Krasan GP, Heuser J, Bullitt E, Smith AL, Hultgren SJ.
Haemophilus influenzae pili are composite structures assembled via the HifB chaperone.
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11913-8. PMID: 8876237.
Hung DL, Knight SD, Woods RM, Pinkner JS, Hultgren SJ.
Molecular basis of two subfamilies of immunoglobulin-like chaperones.
EMBO J. 1996 Aug 1;15(15):3792-805. PMID: 8670884.
Xu Z, Jones CH, Haslam D, Pinkner JS, Dodson K, Kihlberg J, Hultgren SJ.
Molecular dissection of PapD interaction with PapG reveals two chaperone-binding sites.
Mol Microbiol. 1995 Jun;16(5):1011-20. PMID: 7476177.
Striker R, Nilsson U, Stonecipher A, Magnusson G, Hultgren SJ.
Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli.
Mol Microbiol. 1995 Jun;16(5):1021-9. PMID: 7476178.
Jones CH, Pinkner JS, Roth R, Heuser J, Nicholes AV, Abraham SN, Hultgren SJ.
FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae.
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2081-5. PMID: 7892228.
Magnusson G, Hultgren SJ, Kihlberg J.
Specificity mapping of bacterial lectins by inhibition of hemagglutination using deoxy and deoxyfluoro analogs of receptor-active saccharides.
Methods Enzymol. 1995;253:105-14. No abstract available. PMID: 7476379.
Flemmer K, Xu Z, Pinkner JS, Hultgren SJ, and Kihlberg J.
Peptides inhibit complexation of the bacterial chaperone PapD and reveal potential to block assembly of virulence associated pili.
Bioorganic and Medical Chemical Letters. 1995; 5, 927-932.

1994-1985

Tewari R, Ikeda T, Malaviya R, MacGregor JI, Little JR, Hultgren SJ, Abraham SN.
The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity.
Infect Immun. 1994 Dec;62(12):5296-304. PMID: 7960108.
Jacob-Dubuisson F, Pinkner J, Xu Z, Striker R, Padmanhaban A, Hultgren SJ.
PapD chaperone function in pilus biogenesis depends on oxidant and chaperone-like activities of DsbA.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11552-6. PMID: 797210.
Jacob-Dubuisson F, Striker R, Hultgren SJ.
Chaperone-assisted self-assembly of pili independent of cellular energy.
J Biol Chem. 1994 Apr 29;269(17):12447-55. PMID: 7909802.
Striker R, Jacob-Dubuisson F, Freiden C, Hultgren SJ.
Stable fiber-forming and nonfiber-forming chaperone-subunit complexes in pilus biogenesis.
J Biol Chem. 1994 Apr 22;269(16):12233-9. PMID: 7909317.
Kuehn MJ, Jacob-Dubuisson F, Dodson K, Slonim L, Striker R, Hultgren SJ.
Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria.
Methods Enzymol. 1994;236:282-306. No abstract available. PMID: 7968616.
Kuehn MJ, Ogg DJ, Kihlberg J, Slonim LN, Flemmer K, Bergfors T, Hultgren SJ.
Structural basis of pilus subunit recognition by the PapD chaperone.
Science. 1993 Nov 19;262(5137):1234-41. PMID: 790191.
Jones CH, Pinkner JS, Nicholes AV, Slonim LN, Abraham SN, Hultgren SJ.
FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria.
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8397-401. PMID: 8104335.
Hultgren SJ, Abraham S, Caparon M, Falk P, St Geme JW 3rd, Normark S.
Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition.
Cell. 1993 Jun 4;73(5):887-901. Review. No abstract available. PMID: 8098994.
Jacob-Dubuisson F, Kuehn M, Hultgren SJ.
A novel secretion apparatus for the assembly of adhesive bacterial pili.
Trends Microbiol. 1993 May;1(2):50-5. Review. PMID: 7913856.
Dodson KW, Jacob-Dubuisson F, Striker RT, Hultgren SJ.
Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes.
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3670-4. PMID: 8097321.
Jacob-Dubuisson F, Heuser J, Dodson K, Normark S, Hultgren S.
Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins.
EMBO J. 1993 Mar;12(3):837-47. PMID: 8096174.
Tewari R, MacGregor JI, Ikeda T, Little JR, Hultgren SJ, Abraham SN.
Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from the periplasm of Escherichia coli.
J Biol Chem. 1993 Feb 5;268(4):3009-15. PMID: 8094080.
Hultgren SJ, Jacob-Dubuisson F, Jones CH, Branden CI.
PapD and superfamily of periplasmic immunoglobulin-like pilus chaperones.
Adv Protein Chem. 1993;44:99-123. Review. PMID: 8100380.
Slonim LN, Pinkner JS, Branden CI, Hultgren SJ.
Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly.
EMBO J. 1992 Dec;11(13):4747-56. PMID: 1361168.
Jones CH, Jacob-Dubuisson F, Dodson K, Kuehn M, Slonim L, Striker R, Hultgren SJ.
Adhesin presentation in bacteria requires molecular chaperones and ushers.
Infect Immun. 1992 Nov;60(11):4445-51. Review. No abstract available. PMID: 1356928.
Holmgren A, Kuehn MJ, Branden CI, Hultgren SJ.
Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria.
EMBO J. 1992 Apr;11(4):1617-22. PMID: 1348692.
Kuehn MJ, Heuser J, Normark S, Hultgren SJ.
P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips.
Nature. 1992 Mar 19;356(6366):252-5. PMID: 1348107.
Kuehn MJ, Normark S, Hultgren SJ.
Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits.
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10586-90. PMID: 1683704.
Hultgren SJ, Normark S.
Biogenesis of the bacterial pilus.
Curr Opin Genet Dev. 1991 Oct;1(3):313-8. Review. PMID: 1688123.
Hultgren SJ, Normark S, Abraham SN.
Chaperone-assisted assembly and molecular architecture of adhesive pili.
Annu Rev Microbiol. 1991;45:383-415. Review. PMID: 1683764.
Hultgren SJ, Duncan JL, Schaeffer AJ, Amundsen SK.
Mannose-sensitive haemagglutination in the absence of piliation in Escherichia coli.
Mol Microbiol. 1990 Aug;4(8):1311-8. PMID: 1980711.
Lindberg F, Tennent JM, Hultgren SJ, Lund B, Normark S.
PapD, a periplasmic transport protein in P-pilus biogenesis.
J Bacteriol. 1989 Nov;171(11):6052-8. PMID: 2572580.
Hultgren SJ, Lindberg F, Magnusson G, Kihlberg J, Tennent JM, Normark S.
The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus.
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4357-61. PMID: 2567514.
Kihlberg J, Hultgren SJ, Normark S, and Magnusson G.
Probing of the combining site of the PapG adhesin of uropathogenic E. coli bacteria by synthetic analogues of galabiose.
J. Amer. Chem. Soc. 1989; 111: 6364-6368.
Normark S, Hultgren S, Marklund BI, Stromberg N, Tennent J.
Biogenesis of pili adhesins associated with urinary tract infectious Escherichia coli.
Antonie Van Leeuwenhoek. 1988; 54(5): 405-9. No abstract available. PMID: 2904797.
Schaeffer AJ, Schwan WR, Hultgren SJ, Duncan JL.
Relationship of type 1 pilus expression in Escherichia coli to ascending urinary tract infections in mice.
Infect Immun. 1987 Feb; 55(2): 373-80. PMID: 2879794.
Hultgren SJ, Schwan WR, Schaeffer AJ, Duncan JL.
Regulation of production of type 1 pili among urinary tract isolates of Escherichia coli.
Infect Immun. 1986 Dec; 54: 613-20. PMID: 2877947.
Hultgren SJ, Porter TN, Schaeffer AJ, Duncan JL.
Role of type 1 pili and effects of phase variation on lower urinary tract infections produced by Escherichia coli.
Infect Immun. 1985 Nov;50(2):370-7. PMID: 2865209.
Hultgren SJ, and Hidvegi DF.
Improved transmission electron microscopy technique for the study of cytologic material.
Acta. Cytol. 1985; 29:179-183.
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