News
$5.3 million boosts research to fight urinary infections
2012-10-30 01:23:04
By Michael C. Purdy Researchers at Washington University School of Medicine in St. Louis have received a five-year, $5.3 million grant to explore the way gender and age influence susceptibility to urinary tract infections (UTIs), one of the most common bacterial infections. The grant is funded by the Office of Research in Women’s Health (ORWH) and the National Institute of Diabetes and Digestive and Kidney Diseases, both part of the National Institutes of Health (NIH). With the funding, Scott J. Hultgren, PhD, the Helen L. Stoever Professor of Molecular Microbiology and director of the Center for Women’s Infectious Disease Research, will lead a multidisciplinary team of scientists investigating the underlying mechanisms of these infections. PDF
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2012-10-30 01:23:04
By Michael C. Purdy Researchers at Washington University School of Medicine in St. Louis have received a five-year, $5.3 million grant to explore the way gender and age influence susceptibility to urinary tract infections (UTIs), one of the most common bacterial infections. The grant is funded by the Office of Research in Women’s Health (ORWH) and the National Institute of Diabetes and Digestive and Kidney Diseases, both part of the National Institutes of Health (NIH). With the funding, Scott J. Hultgren, PhD, the Helen L. Stoever Professor of Molecular Microbiology and director of the Center for Women’s Infectious Disease Research, will lead a multidisciplinary team of scientists investigating the underlying mechanisms of these infections. PDF
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Book signing ceremony at the National Academy of Sciences
2011-05-24 00:08:57
Scott Hultgren was elected into the National Academy of Sciences in May 2011. He signed the membership book in 2012 (video).
2011-05-24 00:08:57
Scott Hultgren was elected into the National Academy of Sciences in May 2011. He signed the membership book in 2012 (video).
cWIDR held meeting with Broad Institute Collaborators to focus on Antibiotic Resistance
2017-06-06 17:29:04
The Center for Women’s Infectious Disease Research held a meeting with the Broad Institute on Monday, June 5. This meeting was focused on addressing the crisis our medical community is facing in Antibiotic Resistance. They discussed ways to expand their interdisciplinary collaborative efforts to continue to learn from each other and launch new initiatives that will benefit society by leading to practical insights into common infections such as urinary tract infections and catheter associated infections and MRSA. The cWIDR working with the Broad hopes to revolutionize the development of antibiotic sparing therapeutics. The meeting was sponsored by Fimbrion Therapeutics.
2017-06-06 17:29:04
The Center for Women’s Infectious Disease Research held a meeting with the Broad Institute on Monday, June 5. This meeting was focused on addressing the crisis our medical community is facing in Antibiotic Resistance. They discussed ways to expand their interdisciplinary collaborative efforts to continue to learn from each other and launch new initiatives that will benefit society by leading to practical insights into common infections such as urinary tract infections and catheter associated infections and MRSA. The cWIDR working with the Broad hopes to revolutionize the development of antibiotic sparing therapeutics. The meeting was sponsored by Fimbrion Therapeutics.
Doctors Might Stop UTIs From Ever Happening Again
2018-07-10 17:00:58
For Scott Hultgren, urinary tract infections are the canary in the coal mine for antibiotic resistance. “Since the mid 2000s, the difficulty of treating UTIs has been steadily rising,” Hultgreen, director of the Center for Women’s Infectious Disease Research at Washington University School of Medicine in St. Louis, told The Daily Beast. There are around 8 million UTIsdiagnosed each year in the United States, making up around 25 percent of all infections. continue reading
2018-07-10 17:00:58
For Scott Hultgren, urinary tract infections are the canary in the coal mine for antibiotic resistance. “Since the mid 2000s, the difficulty of treating UTIs has been steadily rising,” Hultgreen, director of the Center for Women’s Infectious Disease Research at Washington University School of Medicine in St. Louis, told The Daily Beast. There are around 8 million UTIsdiagnosed each year in the United States, making up around 25 percent of all infections. continue reading
Drug clears chronic urinary infections in mice
2011-11-16 01:27:17
By Michael C. Purdy An experimental treatment for urinary tract infections has easily passed its first test in animals, alleviating weeks-long infections in mice in as little as six hours. “This drug can block the spread of the bacteria that cause urinary tract infections far better than any other previously reported compound,” says senior author Scott J. Hultgren, PhD, the Helen L Stoever Professor of Molecular Microbiology at Washington University School of Medicine in St. Louis. “If it has similar effects in humans, the potential applications would be very exciting.” PDF
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2011-11-16 01:27:17
By Michael C. Purdy An experimental treatment for urinary tract infections has easily passed its first test in animals, alleviating weeks-long infections in mice in as little as six hours. “This drug can block the spread of the bacteria that cause urinary tract infections far better than any other previously reported compound,” says senior author Scott J. Hultgren, PhD, the Helen L Stoever Professor of Molecular Microbiology at Washington University School of Medicine in St. Louis. “If it has similar effects in humans, the potential applications would be very exciting.” PDF
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Fimbrion and GSK Identify Novel, Antibiotic-Sparing Development Candidate for Urinary Tract Infections.
2018-12-10 21:30:59
ST. LOUIS, Dec. 6, 2018 /PRNewswire/ — Fimbrion Therapeutics, Inc. announced that under its joint research collaboration with GSK, researchers have identified an orally available, small molecule development candidate for the treatment and prevention of urinary tract infections (UTIs). Fimbrion and the Discovery Partnerships with Academia (DPAc) team at GSK began their joint research efforts in July of 2016. continue reading
2018-12-10 21:30:59
ST. LOUIS, Dec. 6, 2018 /PRNewswire/ — Fimbrion Therapeutics, Inc. announced that under its joint research collaboration with GSK, researchers have identified an orally available, small molecule development candidate for the treatment and prevention of urinary tract infections (UTIs). Fimbrion and the Discovery Partnerships with Academia (DPAc) team at GSK began their joint research efforts in July of 2016. continue reading
Hultgren elected to National Academy of Medicine
2017-10-16 16:22:43
Microbiologist Scott J. Hultgren, PhD, has been elected to the National Academy of Medicine, a part of the National Academy of Sciences. Membership in the organization is one of the highest honors in the fields of health and medicine in the United States. Click here to learn more. continue reading
2017-10-16 16:22:43
Microbiologist Scott J. Hultgren, PhD, has been elected to the National Academy of Medicine, a part of the National Academy of Sciences. Membership in the organization is one of the highest honors in the fields of health and medicine in the United States. Click here to learn more. continue reading
In mice, vaccine stops urinary tract infections linked to catheters
2014-09-17 13:16:58
The most common type of hospital-associated infection may be preventable with a vaccine, new research in mice suggests. continue reading
2014-09-17 13:16:58
The most common type of hospital-associated infection may be preventable with a vaccine, new research in mice suggests. continue reading
Molecular Insights into Microbial Adhesion
2018-07-26 20:34:44
Klein Thesis Defense: Congratulations to Roger Klein for successfully defending his thesis, “Molecular Insights into Microbial Adhesion,” on July 17th. He will be returning to medical school to complete his combined MD/PhD.
2018-07-26 20:34:44
Klein Thesis Defense: Congratulations to Roger Klein for successfully defending his thesis, “Molecular Insights into Microbial Adhesion,” on July 17th. He will be returning to medical school to complete his combined MD/PhD.
NIH NIDDK highlights studies from the Hultgren lab/cWIDR
2018-02-02 18:04:39
2018-02-02 18:04:39
NIH NIDDK highlights studies from the Hultgren lab/cWIDR
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Painkillers may decrease susceptibility to recurring urinary infections
2014-05-19 18:16:46
Women plagued by repeated urinary tract infections may be able to prevent the infections with help from over-the-counter painkillers, according to research presented at the annual meeting of the American Society for Microbiology. continue reading
2014-05-19 18:16:46
Women plagued by repeated urinary tract infections may be able to prevent the infections with help from over-the-counter painkillers, according to research presented at the annual meeting of the American Society for Microbiology. continue reading
Pilot Grant Program awardees attend cWIDR symposium
2017-04-12 22:09:46
The Washington University Center for Women’s Infectious Diseases Research (cWIDR) held its annual symposium December 1, 2016 on the Medical Campus. The event featured research talks by the 2015-16 awardees of the cWIDR Pilot Grant Program, which aims to bring together researchers across departments to focus on topics related to women’s infectious diseases. The center also announced its 2016-17 Pilot Grant awardees: Justin Fay, PhD, associate professor of genetics; and Kristine M. Wylie, PhD, assistant professor of pediatrics.
2017-04-12 22:09:46
The Washington University Center for Women’s Infectious Diseases Research (cWIDR) held its annual symposium December 1, 2016 on the Medical Campus. The event featured research talks by the 2015-16 awardees of the cWIDR Pilot Grant Program, which aims to bring together researchers across departments to focus on topics related to women’s infectious diseases. The center also announced its 2016-17 Pilot Grant awardees: Justin Fay, PhD, associate professor of genetics; and Kristine M. Wylie, PhD, assistant professor of pediatrics.
Profile of Scott Hultgren published in conjunction with his inaugural PNAS article:
2013-09-04 00:45:28
During her lifetime, an adult woman has a 50% chance of developing a urinary tract infection one of the most common types of infections (1). Most urinary tract infections are caused by strains of the bacterium Escherichia coli, and, for the most part, are easily treated with antibiotics. However, many of these infections become chronic or recurrent because of increasing antibiotic resistance and a variety of other pathogen and host related factors, leaving few treatment options. Scott J. Hultgren, a professor of molecular microbiology and director of the Center for Women’s Infectious Diseases Research at Washington University in St. Louis, investigates the molecular mechanisms by which bacteria establish infections in the urinary tract and evade the body’s innate defenses. PDF
2013-09-04 00:45:28
During her lifetime, an adult woman has a 50% chance of developing a urinary tract infection one of the most common types of infections (1). Most urinary tract infections are caused by strains of the bacterium Escherichia coli, and, for the most part, are easily treated with antibiotics. However, many of these infections become chronic or recurrent because of increasing antibiotic resistance and a variety of other pathogen and host related factors, leaving few treatment options. Scott J. Hultgren, a professor of molecular microbiology and director of the Center for Women’s Infectious Diseases Research at Washington University in St. Louis, investigates the molecular mechanisms by which bacteria establish infections in the urinary tract and evade the body’s innate defenses. PDF
Publication of PNAS article on the process of pore-gating in outermembrane ushers in pilus assembly.
2013-12-02 00:14:50
Extracellular fibers called chaperone-usher pathway pili are critical virulence factors in a wide range of Gram-negative pathogenic bacteria that facilitate binding and invasion into host tissues and mediate biofilm formation. Chaperone-usher pathway ushers, which catalyze pilus assembly, contain five functional domains: a 24-stranded transmembrane β-barrel translocation domain (TD), a β-sandwich plug domain (PLUG), an N-terminal periplasmic domain, and two C-terminal periplasmic domains (CTD1 and 2). Pore gating occurs by a mechanism whereby the PLUG resides stably within the TD pore when the usher is inactive and then upon activation is translocated into the periplasmic space, where it functions in pilus assembly. continue reading
2013-12-02 00:14:50
Extracellular fibers called chaperone-usher pathway pili are critical virulence factors in a wide range of Gram-negative pathogenic bacteria that facilitate binding and invasion into host tissues and mediate biofilm formation. Chaperone-usher pathway ushers, which catalyze pilus assembly, contain five functional domains: a 24-stranded transmembrane β-barrel translocation domain (TD), a β-sandwich plug domain (PLUG), an N-terminal periplasmic domain, and two C-terminal periplasmic domains (CTD1 and 2). Pore gating occurs by a mechanism whereby the PLUG resides stably within the TD pore when the usher is inactive and then upon activation is translocated into the periplasmic space, where it functions in pilus assembly. continue reading
Publication of Scott Hultgren’s Inaugural PNAS article detailing the fine-tuning of host interactions
2013-09-24 00:28:15
This article details the fine-tuning of host interactions by alterations in positively selected residues in the adhesin FimH. The evolution of multidrug resistance in pathogenic bacteria, including uropathogenic Escherichia coli (UPEC), that cause most urinary tract infections is becoming a worldwide crisis. UPEC use a variety of virulence factors and adhesins, including the mannose-binding FimH adhesin, to colonize and invade bladder tissue, often forming intracellular biofilms and quiescent reservoirs that can contribute to recurrent infections recalcitrant to treatment. Using two prototypical UPEC strains, we discovered that positively selected residues outside of the FimH mannose-binding pocket affect transitions between low- and high-affinity FimH conformations, which extraordinarily impacts FimH function during pathogenesis. Thus, this work elucidates mechanistic and functional insights into pathoadaptation and evolutionary fine-tuning of critical virulence interactions. PDF
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2013-09-24 00:28:15
This article details the fine-tuning of host interactions by alterations in positively selected residues in the adhesin FimH. The evolution of multidrug resistance in pathogenic bacteria, including uropathogenic Escherichia coli (UPEC), that cause most urinary tract infections is becoming a worldwide crisis. UPEC use a variety of virulence factors and adhesins, including the mannose-binding FimH adhesin, to colonize and invade bladder tissue, often forming intracellular biofilms and quiescent reservoirs that can contribute to recurrent infections recalcitrant to treatment. Using two prototypical UPEC strains, we discovered that positively selected residues outside of the FimH mannose-binding pocket affect transitions between low- and high-affinity FimH conformations, which extraordinarily impacts FimH function during pathogenesis. Thus, this work elucidates mechanistic and functional insights into pathoadaptation and evolutionary fine-tuning of critical virulence interactions. PDF
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Scott Hultgren and Denise Monack edited a special set of articles in Current Opinions in Microbiology discussing the complex interactions that occur between bacterial pathogens and their hosts
2013-02-01 01:06:19
The introduction of antibiotics into clinical practice in the 1950s led to the presumption that bacterial infectious diseases would become a ‘thing of the past’. While antibiotics have resulted in major decreases in morbidity and mortality in the subsequent decades, the global burden of infectious diseases remains one of the largest challenges facing the international biomedical community. Bacterial diseases that were thought to be defeated are still major health care problems. For example, tuberculosis kills an estimated 3 million individuals per year. Diarrheal diseases, some of which are caused by bacterial infections such as cholera, still affect numerous individuals with severe effects on children in the developing world. Most worrying is the increasing prevalence of bacterial pathogens that are resistant to multiple antibiotics, including some that are resistant to all known antibiotics. Thus, there is a desperate need for novel strategies to successfully treat bacterial infections. PDF
continue reading
2013-02-01 01:06:19
The introduction of antibiotics into clinical practice in the 1950s led to the presumption that bacterial infectious diseases would become a ‘thing of the past’. While antibiotics have resulted in major decreases in morbidity and mortality in the subsequent decades, the global burden of infectious diseases remains one of the largest challenges facing the international biomedical community. Bacterial diseases that were thought to be defeated are still major health care problems. For example, tuberculosis kills an estimated 3 million individuals per year. Diarrheal diseases, some of which are caused by bacterial infections such as cholera, still affect numerous individuals with severe effects on children in the developing world. Most worrying is the increasing prevalence of bacterial pathogens that are resistant to multiple antibiotics, including some that are resistant to all known antibiotics. Thus, there is a desperate need for novel strategies to successfully treat bacterial infections. PDF
continue reading
Transcriptional Signature of Host Susceptibility in Urinary Tract Infections
2018-07-26 20:33:13
Yu Thesis Defense: Congratulations to Lu Yu for successfully defending her thesis, “Transcriptional Signature of Host Susceptibility in Urinary Tract Infections,” on July 12th. She is the 30th PhD graduate from the Hultgren Lab.
2018-07-26 20:33:13
Yu Thesis Defense: Congratulations to Lu Yu for successfully defending her thesis, “Transcriptional Signature of Host Susceptibility in Urinary Tract Infections,” on July 12th. She is the 30th PhD graduate from the Hultgren Lab.
Ushering CUP Pilus Assembly: Dissecting the Mechanics of a Bacterial Nanomachine
2018-07-26 20:35:45
Omattage Thesis Defense: Congratulations to Natalie Omattage for successfully defending her thesis, “Ushering CUP Pilus Assembly: Dissecting the Mechanics of a Bacterial Nanomachine,” on July 19th. She will be moving to Jue Chen’s lab at Rockefeller as a post-doctoral fellow.
2018-07-26 20:35:45
Omattage Thesis Defense: Congratulations to Natalie Omattage for successfully defending her thesis, “Ushering CUP Pilus Assembly: Dissecting the Mechanics of a Bacterial Nanomachine,” on July 19th. She will be moving to Jue Chen’s lab at Rockefeller as a post-doctoral fellow.
UTI treatment reduces E. coli, may offer alternative to antibiotics
2017-05-25 16:33:37
For patients who’ve succeeded in knocking out a bad urinary tract infection (UTI) with antibiotic treatment, it’s frustrating to have that uncomfortable burning sensation flare back up. Researchers are hopeful that this striking work of science and art can help them better understand why severe UTIs leave people at greater risk of subsequent infection, as well as find ways to stop the vicious cycle. For more, see NEWS and VIEWS and listen to a podcast. continue reading
2017-05-25 16:33:37
For patients who’ve succeeded in knocking out a bad urinary tract infection (UTI) with antibiotic treatment, it’s frustrating to have that uncomfortable burning sensation flare back up. Researchers are hopeful that this striking work of science and art can help them better understand why severe UTIs leave people at greater risk of subsequent infection, as well as find ways to stop the vicious cycle. For more, see NEWS and VIEWS and listen to a podcast. continue reading
UTI treatment reduces E. coli, may offer alternative to antibiotics
2017-06-15 18:09:34
Urinary tract infections (UTIs) are among the most common infections, and they tend to come back again and again, even when treated. Most UTIs are caused by E. coli that live in the gut and spread to the urinary tract. continue reading
2017-06-15 18:09:34
Urinary tract infections (UTIs) are among the most common infections, and they tend to come back again and again, even when treated. Most UTIs are caused by E. coli that live in the gut and spread to the urinary tract. continue reading
Valerie O’Brien presented her work on vaccination strategies to prevent recurrent UTI
2014-03-28 14:41:47
Valerie O’Brien presented her work on vaccination strategies to prevent recurrent UTI at the Trainee Oral Symposium at the second annual Global Health and Infectious Disease Conference, sponsored by Washington University School of Medicine and the Washington University Institute for Public Health. Valerie won one of two prizes for best presentation.
2014-03-28 14:41:47
Valerie O’Brien presented her work on vaccination strategies to prevent recurrent UTI at the Trainee Oral Symposium at the second annual Global Health and Infectious Disease Conference, sponsored by Washington University School of Medicine and the Washington University Institute for Public Health. Valerie won one of two prizes for best presentation.Top